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Warner Bros.’ “Clash of the Titans” marched to the top of the box office with a triumphant $61.4 million despite reports of lackluster 3D imagery that the studio through in at the last minute to caputalize on the 3D trend.
The twelve estimated top producing motion pictures for the weekend, per data collected as of Sunday, April 4, 2010 include:
| Rank | Title | Distributor | Weekend Gross | Cume | Locations |
| 1 | Clash Of The Titans | Warner Bros. | $61,400,000 | $61,400,000 | 3777 |
| 2 | Tyler Perry’s Why Did I Get Married Too | Lionsgate | $30,150,000 | $30,150,000 | 2155 |
| 3 | How To Train Your Dragon | Paramount | $29,200,000 | $92,325,872 | 4060 |
| 4 | The Last Song | Disney | $16,203,000 | $25,590,615 | 2673 |
| 5 | Alice In Wonderland | Disney | $8,267,000 | $309,792,693 | 2980 |
| 6 | Hot Tub Time Machine | MGM | $8,000,000 | $27,842,318 | 2771 |
| 7 | The Bounty Hunter | Sony | $6,200,000 | $48,957,393 | 3118 |
| 8 | Diary Of A Wimpy Kid | 20th Century Fox | $5,525,000 | $46,234,281 | 2842 |
| 9 | She’s Out Of My League | Paramount | $1,463,000 | $28,659,022 | 1390 |
| 10 | Shutter Island | Paramount | $1,462,000 | $123,414,534 | 1356 |
| 11 | Green Zone | Universal | $1,217,160 | $33,087,185 | 1242 |
| 12 | The Ghost Writer | Summit Entertainment | $1,135,000 | $11,023,896 | 656 |
