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Fox’s Avatar stacked up another box office win as the film racked up a fourth consecutive box office win. Sherlock Holmes took the second spot, racking up its own considerable box office pot.
The twelve estimated top producing motion pictures for the weekend, per data collected as of Sunday, January 10, 2010 include:
| Rank | Title | Distributor | Weekend Gross | Cume | Locations |
| 1 | Avatar | 20th Century Fox (NYSE:NWS) | 48,500,000 | 429,040,297 | 3422 |
| 2 | Sherlock Holmes | Warner Bros. (NYSE:TWX) | 16,610,000 | 165,177,766 | 3626 |
| 3 | Alvin And The Chipmunks: The Squeakquel | 20th Century Fox (NYSE:NWS) | 16,300,000 | 178,184,676 | 3641 |
| 4 | Daybreakers | Lionsgate (NYSE:LGF) | 15,000,000 | 15,000,000 | 2523 |
| 5 | It’s Complicated | Universal (NYSE:GE) | 11,007,375 | 76,370,040 | 2955 |
| 6 | Leap Year | Universal (NYSE:GE) | 9,165,150 | 9,165,150 | 2511 |
| 7 | The Blind Side | Warner Bros. (NYSE:TWX) | 7,750,000 | 219,196,909 | 2880 |
| 8 | Up In The Air | Paramount (NYSE: VIA and VIA.B) | 7,100,000 | 54,741,741 | 2218 |
| 9 | Youth In Revolt | The Weinstein Company | 7,000,000 | 7,000,000 | 1873 |
| 10 | The Princess and the Frog | Disney (NYSE:DIS) | 4,743,000 | 92,638,571 | 2620 |
| 11 | Invictus | Warner Bros. (NYSE:TWX) | 1,715,000 | 33,499,643 | 1340 |
| 12 | Nine (12/18/09) | The Weinstein Company | 1,618,000 | 16,840,127 | 1060 |
