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Disney’s fantasy Alice in Wonderland shrank al little in its second outing but again topped the box office in a big way, taking in an estimated $62 million over the weekend.
The twelve estimated top producing motion pictures for the weekend, per data collected as of Sunday, March 14, 2010 include:
| Rank | Title | Distributor | Weekend Gross | Cume | Locations |
| 1 | Alice In Wonderland | Disney | $62,000,000 | $208,625,356 | 3728 |
| 2 | Green Zone | Universal | $14,534,520 | $14,534,520 | 3003 |
| 3 | She’s Out Of My League | Paramount | $9,600,000 | $9,600,000 | 2956 |
| 4 | Remember Me | Summit Entertainment | $8,281,000 | $8,281,000 | 2212 |
| 5 | Shutter Island | Paramount | $8,140,000 | $108,007,512 | 3356 |
| 6 | Our Family Wedding | Fox Searchlight | $7,600,000 | $7,600,000 | 1605 |
| 7 | Avatar | 20th Century Fox | $6,600,000 | $730,344,022 | 1718 |
| 8 | Brooklyn’s Finest | Overture Films | $4,290,000 | $21,351,472 | 1939 |
| 9 | Cop Out | Warner Bros. | $4,230,000 | $39,442,666 | 2882 |
| 10 | The Crazies | Overture Films | $3,650,000 | $33,358,368 | 2359 |
| 11 | Percy Jackson & The Olympians: Lightning | 20th Century Fox | $3,125,000 | $82,318,000 | 2175 |
| 12 | Crazy Heart | Fox Searchlight | $3,125,000 | $34,203,105 | 1361 |
