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Sony and MGM’s R-rated comedy version of the cult hit 21 Jump Street opening to a $35 million at the domestic box office. Starring Jonah Hill and Channing Tatum, the buddy comedy take on the classic TV series nabbed the top spot of a relatively weak box office weekend.
The Top-12 grossing motion pictures for the weekend, per data collected as of Sunday, March 18, 2012, is as follows:
| Rank | Film Name | Distributor Name | Weekend Revenue | Cume Revenue | Locs | Loc Avg |
| 1 | 21 Jump Street | Sony | 35,000,000 | 35,000,000 | 3,121 | 11,214 |
| 2 | Dr. Seuss’ The Lorax | Universal | 22,821,295 | 158,444,310 | 3,769 | 6,055 |
| 3 | John Carter | Disney | 13,515,000 | 53,172,453 | 3,749 | 3,604 |
| 4 | Project X | Warner Bros. | 4,005,000 | 48,130,846 | 2,922 | 1,370 |
| 5 | Thousand Words, A | Paramount | 3,750,000 | 12,102,821 | 1,895 | 1,978 |
| 6 | Act Of Valor | Relativity Media | 3,678,000 | 62,398,369 | 2,765 | 1,330 |
| 7 | Safe House | Universal | 2,755,200 | 120,248,295 | 1,920 | 1,435 |
| 8 | Journey 2: The Mysterious Island | Warner Bros. | 2,460,000 | 95,065,686 | 1,935 | 1,271 |
| 9 | Casa De Mi Padre | Lionsgate | 2,200,000 | 2,200,000 | 382 | 5,759 |
| 10 | This Means War | 20th Century Fox | 2,125,000 | 50,524,782 | 1,660 | 1,280 |
| 11 | Silent House | Open Road | 2,084,256 | 10,576,000 | 2,124 | 981 |
| 12 | Vow, The | Sony | 2,075,000 | 121,138,255 | 2,175 | 954 |
